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Making progesterone suppositories

So, are you a trans woman?

If so, you may have wanted to introduce progesterone into your regimen.

Unfortunately, if you’re DIYing like me (… meaning, you’re getting and administrating your HRT without medical supervision), and if you’re living in Europe, you may have noticed that getting progesterone is not an easy task, as most providers are often out of stock.

So, to avoid supply shortages, I bought some progesterone raws, and I tried to make my own progesterone suppositories, based on the guide on HRT Cafe. This is basically how it went 🙂.

Requirements

To make suppositories, you will need:

  • Some Progesterone
    • … that’s a bit obvious. I imported mine from a seller in China, for which I paid 120$ for 100g with shipping (I may have gotten a better price if I purchased a bigger quantity, but I wanted to try first)
  • And some Witepsol W25
    • That’s the suppository base. It’s fat that will melt at body temperature (33.5~35.5ºC), so you can mix the progesterone with it and use it in your butt. I got a kilogram for 60€.
    • Witepsol W25 is not the only suppository base you can use. Some people use PolyBlend Rx (… which is kind of expensive to get in Europe), or coconut oil (though, the suppositories made with that will not withstand room temperature, you will have to keep your progesterone refrigerated, which is kinda bothering when travelling).

And you will need some non-consumable items:

  • A scale, preferably one that has at least a .01 resolution
  • A glass breaker
  • A glass stirring road
  • A pipette
  • A silicone mould sheet. I used these ones.
  • A hot plate. Alternatively, you can use a 3D printer, or, as we will see, a kettle, some water and a bowl.

Preparation

Make sure you have a clean surface before beginning, and make sure you have space to work

Clean thoroughly your tools with isopropyl alcohol, and make sure everything is dry.

First, put your suppository base into the breaker. For about 200 suppositories / 200ml of preparation, I used about 143.3g of Witepsol W25.

Then, turn on your heater, or put the breaker in hot water until the base melts.

When the Witepsol is completely melted, measure 40g of progesterone powder in a separate container, pour it in the Witepsol, and mix until the progesterone dissolves.

Now, with your pipette, put the mixture into the silicone moulds. For the model I got, each cavities is about 1ml, so you can fill them almost completely.

As you can see, with the amount of Witepsol and Progesterone I’ve put, we’re filling about 154 cavities. The target was to make 200 suppositories, so… yeah, oopsie 😅. (What may be a bit bothersome is that, instead of each suppositories having about 200mg of progesterone, they may now have on average about 260mg of progesterone each. It’s not that big of a deal either, but yeah, next time, I will have to add quite a lot more of Witepsol 🙃)

Once done, wait a few minutes, and put the moulds in the freezer so the suppository base can harden (you can let it there for about 20 to 30 minutes).

Remove the suppositories from the freezer and the moulds, and congratulations! You now have progesterone fishes you can put up your butt! 🙂

Oh, and if some fishes break when you unmould them, well, the solution is simple:

Just melt your problems away 🙃 (you can also use your hot plate or 3D printer bed to melt the fishes again)

As usual, it would be better if you (… or I) could get your progesterone from your doctor or pharmacy. Unfortunately, at least for me, that is not really an option 🥲.